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Association between Early Postoperative Systemic Inflammation Response Index and Prolonged Intensive Care Unit Stay
Feyza Kargın1, Ramazan Kargın2, Hicran Özdemir Demir3
1Intensive Care Clinic, Health Sciences University Kartal Dr. Lutfi Kırdar City Hospital, Istanbul, Turkey. feyzakargin@yahoo.com.
Journal of Korean Neurosurgical Society
|June 9, 2026
Summary
Early postoperative systemic inflammation response index (SIRI) can help predict prolonged intensive care unit (ICU) stays in brain tumor patients. Higher SIRI levels are associated with increased ICU length, aiding in resource management.
Area of Science:
- Neurosurgery
- Critical Care Medicine
- Inflammation Biomarkers
Background:
- The systemic inflammation response index (SIRI) is a novel marker for systemic inflammation.
- Optimizing intensive care unit (ICU) resource utilization is crucial in neurosurgery.
Purpose of the Study:
- To evaluate the association between early postoperative SIRI and prolonged ICU stay (>24 hours) after brain tumor (BT) surgery.
- To assess the predictive performance of SIRI for extended ICU admission in this patient cohort.
Main Methods:
- Retrospective analysis of 206 adult patients undergoing elective BT surgery.
- Logistic regression to identify predictors of prolonged ICU stay, including postoperative SIRI.
- Receiver operating characteristic (ROC) curve analysis to determine SIRI's discriminatory power.
Main Results:
- Postoperative SIRI was independently associated with prolonged ICU stay (OR=1.090, p<0.001).
- Hypertension, hemorrhage, cerebral edema, and neurological deficit also predicted longer ICU stays.
- An optimal SIRI cutoff of 10.94 demonstrated an AUC of 0.728 for predicting prolonged ICU stay.
Conclusions:
- Early postoperative SIRI may serve as a valuable adjunctive marker for predicting prolonged ICU stay after BT surgery.
- Integrating SIRI with other clinical parameters can enhance the management of ICU resources.
