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Updated: Aug 5, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

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Serum Uric Acid Is Associated with CT-Derived Aortic Valve Calcification in Low-Flow, Low-Gradient Aortic Stenosis

Anıl Avcı1, Emre Kipritçi1, İbrahim Veyisoğlu1

  • 1Department of Cardiology, Koşuyolu Cardiovascular Training and Research Hospital, Istanbul 34865, Türkiye.

Journal of Cardiovascular Development and Disease
|July 27, 2026
PubMed

Insights

Elevated serum uric acid levels correlate with aortic valve calcification in patients with low-flow, low-gradient aortic stenosis. Higher uric acid may indicate true severe disease, aiding in assessment.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Imaging

Background:

  • Low-flow, low-gradient aortic stenosis (LF-LG AS) with reduced ejection fraction presents diagnostic challenges.
  • Aortic valve calcification (AVC) is linked to fibro-calcific remodeling and oxidative stress.
  • Serum uric acid (SUA), a marker of oxidative stress, may relate to AVC severity.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and aortic valve calcification.
  • To explore SUA as a potential marker for differentiating true severe LF-LG AS from pseudo-severe cases.

Main Methods:

  • Retrospective analysis of 85 patients with LF-LG AS.
  • Quantification of AVC using computed tomography (CT) Agatston method.
  • Classification of patients into true severe and pseudo-severe AS based on sex-specific calcium thresholds.

Main Results:

  • Higher AVC burden was significantly associated with elevated SUA levels (p < 0.001).
  • SUA showed a modest correlation with AVC score (ρ = 0.339, p = 0.002).
  • SUA remained independently associated with CT-defined true severe LF-LG AS in multivariable analysis, with a threshold of 5.45 mg/dL indicating higher likelihood.

Conclusions:

  • Serum uric acid is linked to CT-derived aortic valve calcification.
  • SUA may offer insights into the fibro-calcific remodeling process in LF-LG AS.
  • SUA could serve as a non-invasive biomarker for assessing LF-LG AS severity.
Abstract

Keywords:
aortic stenosisheart failureoxidative stressuric acid

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