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Cytokeratin-Positive Pleomorphic Chest Wall Sarcoma Mimicking MPNST: A Case Report.
Mohammad Alaa Aldakak1, Ahmad Bishr Nasra1, Raneem Ahmad2
1Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.
Cancer Management and Research
|June 9, 2026
Summary
Undifferentiated pleomorphic sarcoma (UPS) of the chest wall is rare and challenging to diagnose. This case highlights diagnostic pitfalls and successful surgical management of a cytokeratin-positive UPS.
Area of Science:
- Oncology
- Surgical Pathology
- Soft Tissue Tumors
Background:
- Undifferentiated pleomorphic sarcoma (UPS) is a high-grade soft-tissue sarcoma lacking specific markers, making it a diagnosis of exclusion.
- Primary chest-wall involvement by UPS is uncommon.
- Epithelial marker expression in UPS can complicate differential diagnosis.
