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TyG Index is Associated with Major Adverse Cardiovascular Events in HIV-Infected Individuals with Cardiovascular

Lina Chen1, Guofeng Fan1, Qianru Yuan1

  • 1Department of Internal Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.

International Journal of General Medicine
|June 9, 2026
PubMed

Insights

The triglyceride-to-glucose (TyG) index is linked to major adverse cardiovascular events (MACE) in patients with coronary artery disease and HIV (CAD-HIV). Higher TyG index predicts increased MACE risk, serving as a valuable biomarker for cardiovascular risk stratification.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomarkers

Background:

  • Coronary artery disease (CAD) in human immunodeficiency virus (HIV) positive patients presents unique cardiovascular challenges.
  • Understanding novel risk factors is crucial for managing major adverse cardiovascular events (MACE) in this population.

Purpose of the Study:

  • To investigate the association between the triglyceride-to-glucose (TyG) index and the risk of MACE in patients with CAD complicated by HIV (CAD-HIV).
  • To evaluate the predictive value of the TyG index for MACE in this specific patient cohort.

Main Methods:

  • A single-center retrospective cohort study included 103 CAD-HIV patients.
  • Data collected included baseline characteristics and TyG index; MACE was the primary endpoint.
  • Statistical analyses involved Cox regression, restricted cubic splines (RCS), ROC curve analysis, and subgroup analysis.

Main Results:

  • A higher TyG index was significantly associated with an increased risk of MACE (P < 0.001).
  • Each 0.1-unit increase in TyG index elevated MACE risk by 42% (HR = 1.42).
  • The TyG index demonstrated favorable predictive performance for 1-year (AUC=0.745) and 3-year (AUC=0.805) MACE.

Conclusions:

  • The TyG index shows a linear association with MACE risk in CAD-HIV patients.
  • The TyG index serves as a simple and effective biomarker for cardiovascular risk stratification in this population.
  • The association between TyG index and MACE risk was notably stronger in non-smokers.
Abstract

Keywords:
CADHIVMACETyG indexassociation study

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