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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

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Techniques of Endoscopic Ossiculoplasty
09:07

Techniques of Endoscopic Ossiculoplasty

Published on: January 26, 2024

[Eosinophilic otitis media].

Anne-Sophie Homøe1, Kasper Aanæs1, Jens Tidemandsen1

  • 1Afdeling for ~re-Næse-Halskirurgi og Audiologi, Københavns Universitetshospital - Rigshospitalet.

Ugeskrift for Laeger
|June 9, 2026
PubMed
Summary
This summary is machine-generated.

Eosinophilic otitis media (EOM), a rare ear condition, often co-occurs with asthma and CRSwNP. Mepolizumab treatment significantly improved symptoms and hearing in two patients with severe EOM.

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Area of Science:

  • Otolaryngology
  • Immunology
  • Allergy

Background:

  • Eosinophilic otitis media (EOM) is a rare, severe middle ear disease.
  • EOM is characterized by eosinophilic secretions and can lead to irreversible hearing loss.
  • It is frequently associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), driven by type-2 inflammation.

Purpose of the Study:

  • To report the efficacy of mepolizumab in treating severe EOM.
  • To evaluate the impact of IL-5 inhibition on EOM symptoms and hearing.
  • To assess the potential of targeted therapy in patients with coexisting asthma and CRSwNP.

Main Methods:

  • Case report of two patients with severe EOM, asthma, and CRSwNP.
  • Patients received treatment with mepolizumab, an IL-5 inhibitor.
  • Outcomes assessed included ear symptoms, hearing levels, and systemic steroid requirements.

Main Results:

  • Mepolizumab treatment led to significant improvement in ear symptoms.
  • Patients experienced enhanced hearing following treatment.
  • The need for systemic steroid therapy was reduced.

Conclusions:

  • Mepolizumab is a promising therapeutic option for severe EOM, particularly in patients with comorbid asthma and CRSwNP.
  • Targeting IL-5 may effectively manage EOM by addressing the underlying type-2 inflammation.
  • Further research is warranted to confirm these findings in larger cohorts.