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Updated: Jun 11, 2026
Synthesis of Triazole and Tetrazole-Functionalized Zr-Based Metal-Organic Frameworks Through Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Zr-functionalized hydrogen-bonded organic framework for magnetic solid-phase extraction and LC-MS/MS determination of
Jiawei Liu1, Minli Yang2, Feng Zhang2
1China National Research Center for Food Safety Inspection and Testing, Beijing 100045, China; Key Laboratory of Food Quality and Safety, State Administration for Market Regulation, Beijing 100045, China; Collaborative Innovation Center, Henan Academy of Sciences, Zhengzhou, Henan 450046, China.
Abstract:
Fluoroquinolone antibiotics (FQs) are frequently detected at trace levels in milk, complicating accurate quantification due to matrix interference and stringent regulatory limits. This study developed a zirconium-functionalized magnetic hydrogen-bonded organic framework (Zr@MHOF101) for selective magnetic solid-phase extraction (MSPE) of six FQs prior to LC-MS/MS analysis. Three π-conjugated carboxylic acid-based HOFs were synthesized and compared. Magnetic functionalization enabled rapid phase separation and altered adsorption behavior, while Zr post-modification increased adsorption selectivity toward FQs in milk matrices. Optimized MSPE enabled rapid enrichment (2 min) using 3 mg adsorbent and 1 g milk, achieving LODs of 0.1-0.2 μg/kg, LOQs of 0.2-0.5 μg/kg, and recoveries of 77.17%-105.49%. Compared to MOF/COF sorbents, Zr@MHOF101 reduced resource use and improved FQs selectivity over other antibiotics, providing a practical tool for monitoring residues in complex food matrices.
