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A preliminary technique development for quantitative analysis of transhumeral bone, post-amputation, using a computed
Kristofer Sinclair1, Zakary Wankier1,2, Kent Bachus1,2
1Department of Veterans Affairs (VA) Office of Research and Development, Rehabilitation Research and Development Service, VA Salt Lake City Health Care System, Salt Lake City, UT, United States of America.
Bone anchored prostheses (BAP) can be an alternative for amputees. This study analyzed bone mineral density (BMD) in transhumeral amputation (THA) patients, finding significantly decreased BMD in the amputated limb, suggesting potential challenges for BAP integration.
Area of Science:
- Orthopedic surgery
- Biomedical engineering
- Radiology
Background:
- Bone anchored prostheses (BAP) offer an alternative to traditional socket prostheses for amputees.
- Progressive bone mineral density (BMD) loss post-amputation can compromise bone strength and implant stability.
- Limited research exists on BAP efficacy and bone adaptation in upper limb amputees.
Purpose of the Study:
- To describe methods for analyzing BMD in individuals with transhumeral amputation (THA).
- To evaluate quantitative differences in BMD between amputated and intact humeri.
- To establish a foundation for clinical assessment of BAP effects on humerus bone remodeling.
Main Methods:
- Quantitative Computed Tomography (QCT) scans were performed on 17 participants with THA using a QCT phantom.
- Modified hip and spine QCT protocols were adapted for humerus BMD analysis.
- Volumetric (vBMD) and total area BMD (aBMD) were calculated using specialized software for amputated and contralateral limbs.
Main Results:
- Six participants (N=6) were included in the final analysis due to software field-of-view limitations.
- A uniform decrease in BMD was observed in the amputated humerus compared to the intact contralateral limb.
- These BMD decreases were statistically significant (p<0.05) across all included participants.
Conclusions:
- Humerus BMD can be successfully analyzed using QCT with modified protocols.
- Preliminary findings indicate significant BMD reduction in the amputated humerus of THA patients.
- The developed techniques will enable clinical evaluation of BAP influence on humerus bone remodeling.
