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Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

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Related Experiment Video

Updated: Jun 11, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
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Published on: March 17, 2022

Navigating Acute Pulmonary Embolism With Dilated Cardiomyopathy and Multisite Thrombosis.

Xiaoyue Qin1, Guobin Song2

  • 1Department of General Practice, Shijiazhuang People's Hospital, Shijiazhuang City, China; Department of Cardiology, Peking University People's Hospital, Beijing City, China.

The American Journal of Cardiology
|June 9, 2026
PubMed
Summary

This case study details a patient with acute pulmonary embolism (PE) and severe heart failure, complicated by widespread thrombosis and liver congestion. Management required tailored anticoagulation and early mechanical interventions for this complex presentation.

Keywords:
TTN truncating variantacute pulmonary embolismdilated cardiomyopathymultisite thrombosis

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Area of Science:

  • Cardiology
  • Pulmonology
  • Genetics

Background:

  • A 60-year-old woman presented with worsening chest discomfort and dyspnea.
  • Medical history included remote hepatitis; physical exam revealed signs of heart failure and elevated cardiac biomarkers.

Purpose of the Study:

  • To describe the complex management of acute pulmonary embolism (PE) in a patient with severe heart failure, multisite thrombosis, and hepatic congestion.
  • To emphasize the importance of individualized anticoagulation and early mechanical interventions.

Main Methods:

  • Computed tomography pulmonary angiography (CTPA) for PE diagnosis.
  • Transthoracic echocardiography for cardiac assessment.
  • Genetic testing for cardiomyopathy variants.

Main Results:

  • CTPA revealed bilateral pulmonary artery thrombi.
  • Echocardiography showed biventricular enlargement (LVEF 20%), left ventricular mural thrombi, and right atrial thrombus.
  • Genetic testing identified a pathogenic TTN truncating variant, consistent with dilated cardiomyopathy (DCM).

Conclusions:

  • Acute PE management was complicated by severe heart failure, multisite thrombosis, and hepatic congestion.
  • Individualized anticoagulation bridging and early mechanical interventions are critical.
  • A TTN variant was associated with the patient's dilated cardiomyopathy phenotype.