Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multicompartment Models: Overview01:14

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Two-Compartment Open Model: IV Infusion01:15

Two-Compartment Open Model: IV Infusion

A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
Compartment Models: Single-Compartment Model01:14

Compartment Models: Single-Compartment Model

The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving CKRT Outcomes in Neonates and Infants through Interdisciplinary Collaboration (ICONIIC): Education Practices and Care Delivery Models.

Nephrology nursing journal : journal of the American Nephrology Nurses' Association·2026
Same author

Corrigendum to "Understanding Carpediem Indications and Outcomes: A Report from the ICONIIC Learning Network" The Journal of Pediatrics, Volume 288 (2026), 114838.

The Journal of pediatrics·2026
Same author

Part 8: Pediatric Advanced Life Support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Pediatrics·2025
Same author

Part 8: Pediatric Advanced Life Support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Circulation·2025
Same author

Infant Renal Replacement Therapy Using Carpediem: A Multicenter Observational Cohort Study from the ICONIIC Learning Network.

The Journal of pediatrics·2025
Same author

A Retrospective Observational Study of Vibrating Mesh Nebulizers in the Pediatric Emergency Department.

Pediatric emergency care·2025

Related Experiment Video

Updated: Jun 11, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

ICU UNITED: A Scalable Model for Cross-Unit Simulation in Critical Care.

Kyle B Lenz1, Ivie D Esangbedo2, Devin A McKissic3

  • 1Division of Pediatric Critical Care Medicine, Seattle Children's Hospital, University of Washington, Seattle, WA.

Chest
|June 9, 2026
PubMed
Summary

Simulation-Based Medical Education (SBME) programs lack standardized guidelines. This critical care program, ICU UNITED, offers a framework for interdisciplinary simulation to improve team collaboration and address system-level challenges.

Keywords:
critical careinterprofessionalmedical educationpediatricssimulation

More Related Videos

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound
05:04

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound

Published on: August 9, 2024

Related Experiment Videos

Last Updated: Jun 11, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound
05:04

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound

Published on: August 9, 2024

Area of Science:

  • Medical Education
  • Healthcare Simulation
  • Critical Care Medicine

Background:

  • Simulation-Based Medical Education (SBME) is widely used but lacks standardized instructional guidelines and program design.
  • Existing SBME programs are often siloed within departments, limiting multidisciplinary collaboration and system-level learning.
  • Variability in techniques, methods, and curricula impacts the effectiveness of SBME.

Purpose of the Study:

  • To describe the ICU UNITED critical care SBME program at Seattle Children's Hospital.
  • To present an instructional framework for organizing SBME programs and designing individual sessions.
  • To address shortcomings in current SBME implementation, promoting interdisciplinary collaboration and system-level learning.

Main Methods:

  • Developed ICU UNITED, an innovative, cross-unit simulation program integrating in situ sessions.
  • Implemented a shared resource model across pediatric, cardiac, and neonatal intensive care units.
  • Created an instructional framework focusing on clear objectives, learner participation, and satisfaction measures.

Main Results:

  • ICU UNITED integrates multidisciplinary teams through a shared resource model.
  • The instructional framework supports longitudinal program organization and session design.
  • The program aims to assess and address system-level challenges through interdisciplinary simulation.

Conclusions:

  • The ICU UNITED program provides a pragmatic model for developing interdisciplinary simulation programs.
  • The presented framework supports program sustainability and growth.
  • This approach enhances collaboration and facilitates the identification and resolution of system-level issues in critical care settings.