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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Intramedullary Spinal Cord Tumors Associated with the Neurofibromatoses
Jesse A Stokum1, Allan J Belzberg2, Jaishri O Blakeley3
1Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Abstract:
The neurofibromatoses (NF) comprise several tumor predisposition conditions, including neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 schwannomatosis (NF2-SWN). Although paraspinal peripheral nerve sheath tumors (including neurofibromas and schwannomas) occur frequently in the NF conditions, there is also a risk of intramedullary spinal cord tumors in people with NF1 and NF2-SWN. Here, we discuss the presentation and diagnosis of the various forms of NF, the intramedullary spinal cord tumors that occur in NF1 and NF2-SWN, and their diagnostic and treatment considerations.
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