Related Experiment Video For 3D histology
Updated: Jun 11, 2026
Generation of an Orthotopic Xenograft of Pancreatic Cancer Cells by Ultrasound-Guided Injection
Published on: November 1, 2021
A PanIN-oramic view of early pancreatic cancer in 3D
Alexander Cicala1, Sebastian A Dziadowicz2, Peter M K Westcott2
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Abstract:
Pancreatic cancer is a deadly disease defined by an immunosuppressive microenvironment refractory to therapy. Kiemen et al. applied 3D histology, imaging mass cytometry, and spatially resolved DNA sequencing to human pancreata containing early precursors of the disease, revealing heterogeneous and mutation-specific inflammatory niches that are poorly resolved by 2D methods.
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