Combined Antibiotic, Steroid, and Moisturizer Therapy in Eczema Treatment: Balancing Short-Term Relief with Long-Term...

Combined antibiotic-corticosteroid-moisturizer therapy, often referred to as the Aron Regimen has gained popularity for managing atopic dermatitis (AD). While this therapy has been shown in some studies to provide short-term improvement in symptoms, evidence for its long-term utility is limited, and its widespread use raises concerns about promoting antibiotic resistance and disrupting the skin microbiome. Studies suggest that topical antibiotics provide limited benefit for most eczema cases, with only modest or context-specific benefits reported in more severe or treatment-resistant situations. Importantly, current clinical guidelines do not recommend the routine use of topical antimicrobials in the absence of clear infection. This review contextualizes the Aron Regimen within current evidence and emphasizes a more cautious, limited role for antibiotic-containing therapies in AD.