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Juvenile recurrent parotitis: a paediatric rheumatology perspective
Didem Öztürk1, Elif Çelikel1, Zahide Ekici Tekin1
1Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey.
Insights
Juvenile recurrent parotitis (JRP) is often idiopathic, but underlying causes like immune deficiencies, autoimmune conditions, or infections can be present in some children. This study evaluated JRP patient characteristics and potential underlying factors.
Area of Science:
- Pediatrics
- Immunology
- Otolaryngology
Background:
- Juvenile recurrent parotitis (JRP) is a rare condition affecting children.
- Understanding the diverse etiology of JRP is crucial for effective management.
Purpose of the Study:
- To analyze demographic, clinical, laboratory, and imaging findings in pediatric patients diagnosed with JRP.
- To investigate the underlying causes and treatment outcomes for juvenile recurrent parotitis.
Main Methods:
- An observational study involving a review of medical records of patients aged 1-18 years diagnosed with JRP.
- Data collected included patient demographics, clinical presentation, laboratory results, imaging studies, and treatment strategies.
Main Results:
- The study included 46 JRP patients; 58.7% were male, with a median age at onset of 4 years.
- Idiopathic cases comprised 80.4%; other causes included inborn errors of immunity (6.5%), rheumatologic conditions (4.3%), and infectious diseases (4.3%).
- Sjögren syndrome and IgG4-related disease were identified in a small percentage of patients.
Conclusions:
- While most juvenile recurrent parotitis cases are idiopathic, a significant minority present with underlying infectious, structural, immunologic, or autoimmune abnormalities.
- Comprehensive evaluation is necessary to identify potential contributing factors beyond idiopathic causes in JRP patients.
Objective:
The purpose of this study was to evaluate the demographic characteristics, clinical and laboratory findings, imaging methods and treatment of juvenile recurrent parotitis (JRP) patients.
Method:
This observational medical record study was conducted in patients, aged 1 to18 years, were diagnosed with JRP.
Results:
Of the 46 patients with JRP included, 27 (58.7%) were male. The median age at onset was 4 years, and the median age at diagnosis was 6.5 years. Thirty-seven (80.4%) of JRP patients were idiopathic. The underlying causes were as follow: inborn errors of immunity (n = 3, 6.5%), rheumatologic (n = 2, 4.3%), infectious diseases (n = 2, 4.3%), congenital anomaly (n = 431, 2.2%), and one patient (2.2%) had both rheumatologic disease and inborn errors of immunity. Two patients (4.3%) were diagnosed with Sjögren syndrome, and one patient (2.2%) was diagnosed with IgG4-related disease.
Conclusion:
Although most JRP is idiopathic, some patients may have infectious, structural, immunologic or autoimmune abnormalities.
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