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Related Experiment Video

Updated: Jun 11, 2026

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Sphingolipid Signaling in Vascular Smooth Muscle Cells during Development and Diseases.

Irusha Dahal1, Christine Sanderson1, Junichi Saito1

  • 1Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.

JMA Journal
|June 10, 2026
PubMed
Summary

Sphingolipids, like sphingosine-1-phosphate (S1P), are key cell membrane components regulating vascular smooth muscle cell (VSMC) functions. Targeting S1P signaling in VSMCs offers potential therapeutic strategies for cardiovascular diseases.

Keywords:
smooth musclesphingolipidssphingosine kinasesphingosine-1-phosphate receptorsvascular remodeling

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Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

Area of Science:

  • Cell Biology
  • Cardiovascular Research
  • Biochemistry

Background:

  • Sphingolipids are vital cell membrane components metabolized into signaling molecules like sphingosine-1-phosphate (S1P).
  • S1P regulates cellular processes including survival, proliferation, and migration via S1P receptors (S1PRs).
  • Dysregulated sphingolipid signaling contributes to cardiovascular pathologies like atherosclerosis and pulmonary hypertension.

Purpose of the Study:

  • To review the role of sphingolipid signaling in vascular smooth muscle cells (VSMCs).
  • To highlight the involvement of S1P signaling in cardiovascular diseases.
  • To emphasize the therapeutic potential of targeting VSMC sphingolipid signaling.

Main Methods:

  • Literature review of sphingolipid metabolism and signaling pathways.
  • Analysis of S1P and S1PR roles in cardiovascular development and disease.
  • Examination of pharmacological interventions targeting the S1PR pathway.

Main Results:

  • Impaired S1P signaling causes embryonic lethality due to vascular defects in mice.
  • Abnormal sphingolipid signaling in VSMCs promotes excessive proliferation and migration in vascular diseases.
  • S1PR pathway inhibition is a clinically available therapeutic strategy.

Conclusions:

  • Sphingolipid signaling critically influences cardiovascular health and disease.
  • Targeting sphingolipid signaling in VSMCs presents a promising therapeutic avenue for cardiovascular diseases.
  • Further research into VSMC-specific sphingolipid modulation is warranted for effective treatment strategies.