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Related Concept Videos

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Elastin is Responsible for Tissue Elasticity

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Extracellular Matrix01:26

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Related Experiment Video

Updated: Jun 16, 2026

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
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Elastin Regulates Vascular Smooth Muscle Cell Behavior During Development and in Diseases.

Junichi Saito1,2, Irusha Dahal1, Christine Sanderson1

  • 1Vascular Biology Center, Department of Pediatrics, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.

Pediatrics International : Official Journal of the Japan Pediatric Society
|June 15, 2026
PubMed
Summary

Elastic fibers and vascular smooth muscle cells (VSMCs) interact in artery walls. Dysfunction causes VSMC accumulation and disease, but is vital for ductus arteriosus closure.

Keywords:
aortaductus arteriosuselastinsmooth musclevascular remodeling

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Related Experiment Videos

Last Updated: Jun 16, 2026

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

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Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
08:28

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Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

Area of Science:

  • Cardiovascular Biology
  • Extracellular Matrix Research
  • Vascular Physiology

Background:

  • Elastic fibers are vital for arterial elasticity and blood supply.
  • Vascular smooth muscle cells (VSMCs) and elastic fibers form organized arterial media.
  • VSMCs produce tropoelastin, elastic fiber precursor, and respond to elastic fiber signals.

Purpose of the Study:

  • To review elastic fiber formation and deficiency in the aorta and ductus arteriosus.
  • To explore elastin deficiency-induced VSMC accumulation in arteries.
  • To highlight the dual role of elastin deficiency in disease and development.

Main Methods:

  • Literature review of elastic fiber biology.
  • Analysis of VSMC-extracellular matrix interactions.
  • Comparative study of aorta and ductus arteriosus physiology.

Main Results:

  • Elastic fiber dysfunction leads to VSMC accumulation and disease exacerbation.
  • Physiological elastin deficiency and VSMC accumulation are crucial for ductus arteriosus closure.
  • A complex interplay exists between elastic fibers and VSMCs in arterial health and disease.

Conclusions:

  • Elastic fiber integrity is critical for maintaining vascular homeostasis.
  • Understanding elastin-VSMC interactions offers insights into arterial diseases and developmental processes.
  • Targeting these interactions may hold therapeutic potential for vascular conditions.