Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ten-Year Epidemiology and Antimicrobial Susceptibility of Pediatric Staphylococcal Scalded Skin Syndrome: A Retrospective Study From a Tertiary Referral Center.

Pediatric dermatology·2026
Same author

Brain Abscess Clinical Presentation, Microbiology, Management, and Outcome: Evidence from a Tertiary Pediatric Center.

Turkish archives of pediatrics·2026
Same author

An Extremely Rare Case of Sequential Onset of Streptococcal Toxic Shock Syndrome and Kawasaki Disease Following Varicella Infection in a 2.5-Year-Old Girl.

Turkish archives of pediatrics·2026
Same author

Public health perspective of the psychosocial dimensions of paediatric asthma care during crises.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit·2026
Same author

Shigella flexneri 1c bacteremia in a child: a case report.

Gut pathogens·2026
Same author

Association of blood pressure control, lifestyle and socioeconomic status with self-rated health in patients with hypertension: a national cross-sectional study.

BMJ open·2025
Same journal

Ganciclovir Therapeutic Drug Monitoring in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same journal

Commentary on "Examining the Evidence Around Acetaminophen and Autism Risk".

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same journal

Sweet or Salty: Comparing Dextrose and Sodium Acetate Umbilical Arterial Catheter Fluids.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same journal

A Case of Prolonged Serotonin Toxicity After Fluoxetine Ingestion in an Adolescent Patient.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same journal

Efficacy and Safety of Tranexamic Acid in Pediatric Trauma: A Systematic Review and Meta-Analysis.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same journal

Heparin Resistance - A Reality or Fallacy.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

First Infant Desensitization to Liposomal Amphotericin B.

Maryam Rostamyan1, Shirin Chinehkesh2, Mahmoud Khodabandeh3

  • 1Department of Infectious Diseases (MR), Hakim Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|June 10, 2026
PubMed
Summary
This summary is machine-generated.

A 7-month-old infant with visceral leishmaniasis experienced anaphylaxis to liposomal amphotericin B. A desensitization protocol enabled safe treatment completion, marking the first successful use in an infant under one year.

Keywords:
anaphylaxisdesensitizationinfantleishmaniasisliposomal amphotericin B

Related Experiment Videos

Last Updated: Jun 11, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Pharmacology
  • Immunology

Background:

  • Visceral leishmaniasis (VL) is treated with liposomal amphotericin B (LAB).
  • Anaphylaxis to LAB presents a significant challenge in VL management.
  • Desensitization protocols offer an alternative when standard treatment is not tolerated.

Purpose of the Study:

  • To report the successful use of a liposomal amphotericin B desensitization protocol in an infant with visceral leishmaniasis and anaphylaxis.
  • To demonstrate the feasibility and safety of this protocol in young children.

Main Methods:

  • A 7-month-old infant diagnosed with visceral leishmaniasis and hemophagocytic lymphohistiocytosis received liposomal amphotericin B.
  • The patient developed anaphylaxis after the initial dose.
  • A 14-step desensitization protocol was initiated and successfully completed.

Main Results:

  • The desensitization protocol allowed for the continuation of liposomal amphotericin B therapy without further complications.
  • The patient's clinical symptoms (fever, splenomegaly) resolved, and hematological parameters improved post-treatment.
  • Causality assessment indicated a probable adverse drug reaction to liposomal amphotericin B.

Conclusions:

  • Liposomal amphotericin B desensitization is a safe and feasible option for managing anaphylaxis in infants with visceral leishmaniasis.
  • This case highlights the importance of desensitization protocols in endemic areas where VL is prevalent.