Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
Meiosis I03:09

Meiosis I

Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal Consumption of Artificially Sweetened Beverages in Pregnancies and Biomarkers of Fecundity in Adult Sons.

Andrology·2026
Same author

Subjective biology: how perceived fecundity influences relationship satisfaction and stability.

Journal of biosocial science·2026
Same author

Intrauterine Growth and Male Reproductive Health: A Follow-up Study From the Danish National Birth Cohort.

Andrology·2026
Same author

Study of Bladder Cancer Detection in Standard White Light Versus AI-Supported Endoscopy-02 (RAISE-02)-A Randomized Controlled Non-Inferiority Trial.

Cancers·2026
Same author

Pubertal timing and tempo and depression risk in adolescent boys and girls: A Danish population-based cohort study.

Journal of affective disorders·2026
Same author

General practitioner utilization by age, sex and disease in Norway from 2012-2023: a national health registry study.

Scandinavian journal of primary health care·2026

Related Experiment Video

Updated: Jun 12, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

Intergenerational fecundity and infertility: a cohort study.

Mette Viola Stokholm1, Andreas Ernst2, Siri Eldevik Håberg3

  • 1Department of Public Health, Aarhus University, Aarhus, Denmark.

Fertility and Sterility
|June 10, 2026
PubMed
Summary

Longer parental time to pregnancy (TTP) and maternal infertility history increase infertility risk in adult offspring. These findings suggest potential intergenerational transmission of reduced fecundity.

Keywords:
Prenatal exposures delayed effectsassisted reproductive technologycohort studyfecundabilitytime to pregnancy

More Related Videos

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Related Experiment Videos

Last Updated: Jun 12, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Area of Science:

  • Reproductive Health
  • Human Reproduction
  • Epidemiology

Background:

  • Infertility affects a significant portion of the population.
  • Understanding risk factors for infertility is crucial for reproductive health.
  • Potential intergenerational influences on fertility warrant investigation.

Purpose of the Study:

  • To examine the association between parental time to pregnancy (TTP) and maternal infertility history with the risk of infertility in adult offspring.
  • To investigate potential intergenerational transmission of infertility.

Main Methods:

  • A cohort study of 11,144 adult sons and daughters from the Danish Health Habits for Two cohort (1984-1987).
  • Parental TTP categorized as 1-6, 7-12, and >12 months.
  • Maternal infertility history defined by self-report or register diagnosis prior to index pregnancy.
  • Offspring infertility defined by ICD-10 diagnosis or assisted reproductive technology treatment.

Main Results:

  • Longer parental TTP (>12 months) was associated with increased infertility risk in sons (HR 1.25) and daughters (HR 1.41).
  • Maternal history of infertility was linked to higher offspring infertility risk in both sons (HR 1.81) and daughters (HR 1.49).
  • Dose-response trends were observed for TTP in daughters and a modest trend in sons.

Conclusions:

  • Extended parental TTP and maternal infertility history are associated with increased infertility risk in adult offspring.
  • Findings suggest possible intergenerational transmission of low fecundity.
  • Further research is needed to confirm these associations and elucidate underlying mechanisms.