Related Experiment Video
Updated: Jun 12, 2026
03:28
Sperm Collection of Differential Quality Using Density Gradient Centrifugation
Published on: November 29, 2018
Clinical considerations in donor sperm use
Laura C Gemmell1, Iris Insogna1
1Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, Division of Reproductive Endocrinology and Infertility, Columbia University Fertility Center, New York, New York.
Fertility and Sterility
|June 10, 2026
Summary
Donor sperm insemination is rising, requiring careful medical, genetic, and psychosocial evaluations for recipients and donors. This review guides clinicians through recipient screening, donor selection, and emerging challenges in reproductive care.
Area of Science:
- Reproductive Medicine
- Genetics
- Psychosocial Health
Background:
- Donor sperm insemination has significantly increased over the last 20 years.
- This rise necessitates comprehensive guidance for healthcare providers.
- Managing medical, genetic, psychosocial, and regulatory aspects is crucial.
Purpose of the Study:
- To provide a comprehensive review of donor sperm insemination considerations.
- To summarize best practices for recipient evaluation and donor selection.
- To address emerging challenges in contemporary reproductive care.
Main Methods:
- Literature review of current guidelines and research.
- Synthesis of information on recipient assessment, donor selection, and counseling.
- Discussion of legal and ethical considerations.
Main Results:
- Recommended recipient evaluation includes ovarian reserve, uterine/tubal assessment, infectious disease, and carrier screening.
- Key principles for donor selection and genetic reconciliation are outlined.
- Guidance on directed/nondirected donors, counseling, and practical aspects is provided.
Conclusions:
- Clinicians need to navigate complex medical, genetic, and psychosocial factors in donor insemination.
- Emerging issues like donor anonymity and direct-to-consumer genetic testing require attention.
- Evolving perspectives of donor-conceived individuals are shaping reproductive care practices.
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