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Updates in Childhood Acute Lymphoblastic Leukemia

Sara Zarnegar-Lumley1, Jennifer L McNeer2

  • 1Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Hematology/Oncology Clinics of North America
|June 10, 2026
PubMed

Recent molecular studies have identified subgroups of acute lymphoblastic leukemia (ALL) driven by genomic aberrations rather than structural chromosome rearrangements or aneuploidy. Recent years have brought the advent of immunotherapy to cancer treatment regimens, and several effective agents have been developed for B-ALL. With increasing knowledge of molecular drivers of pediatric ALL and the identification of potential targets widely expressed on leukemic blasts, targeted agents and immunotherapies have been developed for pediatric patients with R/R-ALL.

Keywords:
ImmunotherapyPediatric acute leukemiaPh-like ALLTargeted therapy

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