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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

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Subsequent Malignant Neoplasms in Childhood Cancer Survivors: Identifying Risks and Screening Recommendations.

Kerri Becktell¹, Kelly Cotchett², Rebecca Volmy²

¹Division of Pediatric Hematology/Oncology/BMT, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

Hematology/Oncology Clinics of North America

|June 10, 2026

Summary

Subsequent malignant neoplasms (SMNs) are new cancers developing after primary cancer treatment, with risks ranging from 2% to 20%. Understanding risk factors like radiation, chemotherapy, genetics, and lifestyle is crucial for tailored survivor screening.

Keywords:

Cancer screening Childhood cancer survivor Long-term follow-up Subsequent malignant neoplasm

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Area of Science:

Oncology
Cancer Survivorship Research
Preventive Medicine

Background:

Subsequent malignant neoplasms (SMNs) are new cancers diagnosed after primary cancer treatment or stem cell transplant.
Survivor risk for SMNs ranges significantly, estimated between 2% and 20%.

Purpose of the Study:

To highlight the importance of understanding various risk factors for SMNs.
To emphasize the need for individualized SMN screening recommendations for cancer survivors.

Main Methods:

Review of existing literature on SMN risk factors.
Analysis of factors contributing to SMN development in cancer survivors.

Main Results:

Identified key risk factors including radiation, chemotherapy, genetic predispositions, and lifestyle choices.
Highlighted the variability in SMN risk among survivors.

Conclusions:

Comprehensive understanding of individual risk factors is essential for effective SMN screening.
Personalized screening strategies are necessary to manage the long-term risk of SMNs in cancer survivors.