Related Experiment Video

Updated: Jun 12, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

Acute kidney injury is associated with decreased platelet function in domestic cats

Matthew R Kornya1, Shauna L Blois1, Anthony C G Abrams-Ogg1

  • 1Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Journal of Veterinary Internal Medicine
|June 11, 2026
PubMed

Insights

Cats with acute kidney injury (AKI) exhibit platelet dysfunction, as shown by abnormal results on Platelet Function Analyzer-200 (PFA-200) and Multiplate® (MP) assays. This dysfunction may impact clinical procedures in affected felines.

Area of Science:

  • Veterinary Medicine
  • Nephrology
  • Hematology

Background:

  • Acute kidney injury (AKI) is linked to platelet dysfunction in various species, but this association is understudied in cats.
  • Platelet function analyzers like the Platelet Function Analyzer-200 (PFA-200) and Multiplate® (MP) assess platelet activity through distinct mechanisms.

Purpose of the Study:

  • To investigate platelet function in cats diagnosed with AKI using PFA-200 and MP assays.
  • To determine if cats with AKI demonstrate impaired platelet function compared to healthy controls.

Main Methods:

  • The study included 15 cats with AKI and 15 healthy control cats.
  • Platelet function was evaluated using PFA-200 collagen/adenosine diphosphate (Col/ADP) and MP assays (ADP, Col, ASPI).
  • Associations between platelet parameters, AKI status, AKI cause, and azotemia severity were analyzed.

Main Results:

  • Cats with AKI showed significantly prolonged PFA-200 Col/ADP closure times and reduced MP assay responses (ADP, Col, ASPI) compared to controls.
  • Ureteral obstruction in AKI cats was associated with longer PFA-200 closure times but not with MP assay results.
  • No correlation was found between the severity of azotemia or urine specific gravity and platelet function parameters in cats with AKI.

Conclusions:

  • Cats experiencing AKI exhibit evidence of platelet dysfunction.
  • The clinical significance of this platelet dysfunction in cats with AKI is currently unknown.
  • Consideration of platelet dysfunction is recommended for cats with AKI undergoing invasive procedures.
Abstract

Keywords:
aggregometryazotemiakidney injuryplatelet aggregation

More Related Videos

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...