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Related Experiment Video

Updated: Jun 12, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

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Published on: November 5, 2019

Sickle Cell Disease: Historical Overview and Current Therapies.

Oluwaseun O Babatunde¹, Madeleine G Bibby¹, Anthony Atala¹

¹Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA.

Prenatal Diagnosis

|June 11, 2026

Summary

Sickle cell disease (SCD) affects millions globally. In utero transplantation (IUTx) offers a potential cure before birth, avoiding current treatment limitations and risks.

Keywords:

HSC transplantation clinical management hematopoietic stem cell (HSC)pathophysiology sickle cell disease

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Last Updated: Jun 12, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

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Published on: November 5, 2019

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Hematology
Genetics
Pediatric Medicine

Background:

Sickle cell disease (SCD) is a prevalent genetic disorder with limited therapeutic options.
Current treatments, including hematopoietic stem cell (HSC) transplantation, have significant risks and side effects.
SCD manifestations begin in infancy, posing a risk of irreversible organ damage.

Purpose of the Study:

To review the history and current limitations of SCD treatments.
To introduce in utero transplantation (IUTx) as a potential curative therapy for SCD.
To highlight the benefits of treating SCD before birth.

Main Methods:

Literature review of SCD history and treatments.
Conceptual overview of in utero transplantation (IUTx) for SCD.
Analysis of current therapeutic challenges and unmet needs.

Main Results:

Existing SCD treatments are insufficient and carry substantial risks.
Hematopoietic stem cell (HSC) transplantation is curative but challenging.
In utero transplantation (IUTx) presents a novel approach to correct SCD prenatally.

Conclusions:

There is an urgent need for novel, curative SCD therapies.
In utero transplantation (IUTx) could prevent disease onset and lifelong complications.
Prenatal treatment of SCD offers a promising alternative to postnatal interventions.