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Curcumin-loaded nanocarriers for dermatological applications: current advances and biomedical implications.
Tanuj Sharma1, Jagdeep Singh1, Vishal Sharma1
1M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Haryana, India.
EXCLI Journal
|June 11, 2026
Summary
Nanotechnology innovations significantly enhance topical drug delivery for skin disorders, overcoming limitations of conventional methods. Novel formulations improve skin penetration, controlled release, and therapeutic outcomes for conditions like eczema and psoriasis.
Area of Science:
- Dermatology and Nanomedicine
- Pharmaceutical Sciences
- Materials Science
Background:
- Conventional topical formulations face challenges including systemic toxicity, poor skin permeability, and limited drug stability.
- Nanotechnology offers advanced delivery carriers like solid lipid nanoparticles, nanoemulsions, and transdermal patches to overcome these limitations.
- Emerging systems such as cubosomes, nanogels, and microsponges are under investigation for enhanced therapeutic efficacy.
Purpose of the Study:
- To review the advancements in nanotechnology-enabled topical and transdermal drug delivery platforms.
- To explore the clinical applications, technical developments, and use of natural bioactives in dermatological treatments.
- To highlight the importance of novel formulations in addressing skin barrier issues and improving patient outcomes.
Main Methods:
- Review of recent scientific literature and biostatistics (2023-2024) on topical and transdermal delivery systems.
- Analysis of nanotechnology-based carriers including nanoparticles, nanoemulsions, nanogels, and microsponges.
- Examination of clinical trial data for novel delivery systems in treating dermatological conditions.
Main Results:
- Nanotechnology platforms significantly improve skin penetration, controlled drug release, and absorption.
- Hydrogel-based and nanoemulgel formulations show substantial growth and effectiveness.
- Novel systems demonstrate efficacy in treating atopic dermatitis, psoriasis, and eczema, with natural compounds like curcumin showing promise.
Conclusions:
- Nanotechnology-driven topical delivery systems offer superior solutions compared to conventional methods.
- Advanced formulations are crucial for enhancing therapeutic effectiveness and patient outcomes in dermatology.
- The integration of natural bioactives like curcumin within these novel systems holds significant therapeutic potential.
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