Related Experiment Video

Updated: Jun 12, 2026

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess
03:42

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess

Published on: March 15, 2024

Frequency and predictors of small intestinal bacterial overgrowth in acute pancreatitis

Chidanand Kumbar1, Venkatesh Vaithiyam1, Ravi Teja Reddy1

  • 1Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi 110002, Delhi, India.

World Journal of Gastrointestinal Pharmacology and Therapeutics
|June 11, 2026
PubMed
Abstract

Insights

Small intestinal bacterial overgrowth (SIBO) is common in acute pancreatitis (AP), affecting 40% of patients and correlating with disease severity. Identifying SIBO in AP may offer new treatment avenues.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Internal Medicine

Background:

  • Acute pancreatitis (AP) is linked to intestinal issues like dysmotility and dysbiosis, potentially increasing small intestinal bacterial overgrowth (SIBO) risk.
  • Limited evidence exists on SIBO prevalence and clinical factors in AP patients.

Purpose of the Study:

  • To determine the frequency of SIBO in patients diagnosed with AP.
  • To identify clinical, laboratory, and imaging predictors associated with SIBO in AP.

Main Methods:

  • A case-control study involving 30 AP patients and 60 healthy controls (HC) was conducted in New Delhi.
  • The glucose hydrogen breath test was employed for SIBO diagnosis.
  • Predictors of SIBO were analyzed using univariate methods.

Main Results:

  • SIBO was significantly more prevalent in AP cases (40.0%) compared to HC (1.7%).
  • SIBO frequency increased with AP severity: 100% in severe, 75% in moderate-severe, and 11.1% in mild AP.
  • Factors like abdominal bloating, obstipation, severe pancreatitis, ileus, SIRS, acute necrotic collection, high CTSI, elevated NLR, creatinine, and hs-CRP were linked to SIBO.

Conclusions:

  • SIBO is a frequent complication of AP, strongly associated with disease severity.
  • Further prospective research is needed to explore if SIBO diagnosis and treatment can improve AP outcomes.
Keywords:
Acute pancreatitisGlucose hydrogen breath testGut dysbiosisMethaneSmall intestinal bacterial overgrowth

More Related Videos

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...