Related Experiment Video
Updated: Jun 12, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Association of cognitive impairment and APOE ε4 with Centiloids in Hispanic and non-Hispanic White cohorts
Cally Xiao1, Tyler Ard1, Ganna Blazhenets2
1Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Introduction:
Weak associations of apolipoprotein E (APOE) ε4 with cognitive impairment have been reported in Hispanic cohorts. To determine if APOE ε4 associates with brain amyloid load differently in Hispanic and non-Hispanic White (NHW) cohorts, we analyzed reported Centiloid values from studies that conducted amyloid positron emission tomography.
Methods:
This meta-analysis included 17,017 participants (8.4% Hispanic) from five source studies. Analysis of covariance and logistic regression models adjusting for age, sex, education, and cognitive score were applied.
Results:
Although cognitive impairment and APOE ε4 were associated with higher Centiloids in both Hispanic and NHW cohorts, cognitively impaired and APOE ε4 positive Hispanic participants had lower Centiloids than NHW participants with the same conditions.
Discussion:
APOE ε4 may have a weaker influence on brain amyloid load in Hispanic cohorts. Further comparative analyses are necessary for Alzheimer's disease anti-amyloid treatments to be widely applicable to Hispanic populations.
More Related Videos
09:34Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
06:46Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
Published on: August 4, 2018
Related Concept Videos
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Bias in Epidemiological Studies
Pharmacogenomics: Identification of New Drug Targets