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Updated: Jun 12, 2026
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Lower-Limb Biomechanical Characteristics Associated with Unplanned Gait Termination Under Different Walking Speeds
Published on: August 25, 2020
Reduced Gait Speed Is Associated With Poor Prognosis in Patients With Peripheral Artery Disease After
Koya Takino1,2, Yoji Kuze2, Masaya Hori2
1Department of Physical Therapy, School of Health Sciences, Toyohashi Sozo University, Toyohashi, Aichi, Japan (Dr Takino).
Journal of Cardiopulmonary Rehabilitation and Prevention
|June 11, 2026
Summary
Gait speed is a better predictor of outcomes in peripheral artery disease (PAD) patients after endovascular treatment (EVT) than muscle strength. Reduced gait speed indicates higher risk for mortality and adverse events.
Area of Science:
- Vascular Medicine
- Geriatrics
- Rehabilitation Medicine
Background:
- Peripheral artery disease (PAD) impacts lower extremity function and carries a high risk of cardiovascular events post-treatment.
- Current risk stratification often overlooks distal muscle dysfunction, focusing instead on proximal muscle mass.
- Endovascular treatment (EVT) improves PAD symptoms but does not fully mitigate long-term cardiovascular risks.
Purpose of the Study:
- To evaluate the prognostic value of gait speed compared to systemic muscle indicators in PAD patients undergoing EVT.
- To determine if distal muscle function (gait speed) is a superior predictor of adverse outcomes than proximal muscle strength (IKES, GS).
Main Methods:
- A cohort of 248 PAD patients receiving EVT was analyzed.
- Gait speed, isometric knee extensor strength (IKES), and grip strength (GS) were measured and categorized.
- The primary outcome was a composite of all-cause mortality and major adverse cardiovascular and limb events, analyzed using survival analysis.
Main Results:
- Reduced gait speed (<1.0 m/s) was significantly associated with a higher rate of the primary outcome (P < .001).
- Reduced IKES also showed an association (P = .016), but grip strength did not (P = .184).
- After adjustment, only reduced gait speed remained an independent predictor (HR = 2.38, P = .007).
Conclusions:
- Reduced gait speed is a significant independent predictor of adverse outcomes in PAD patients post-EVT.
- Gait speed appears to be a more valuable risk stratification tool than IKES or GS for this patient population.
- Further research is warranted to confirm gait speed's role in managing PAD patients.
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