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Related Experiment Video

Updated: Jun 12, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

3D Printed Angiogenin-Functionalized Bioresorbable Tubular Conduits for Biological Vascularization.

Tanutrushna Sahoo1,2, Samir Das1, Sheeba Sonali1

  • 1School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal 721302, India.

ACS Applied Bio Materials
|June 11, 2026
PubMed
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This summary is machine-generated.

This study developed a 3D-printed silk fibroin-gelatin methacrylate stent functionalized with angiogenin. This bioresorbable vascular scaffold shows promise for cardiovascular regeneration due to its mechanical properties and pro-angiogenic activity.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cardiovascular Research

Background:

  • Vascular damage and obstruction cause severe pathological conditions, contributing significantly to mortality.
  • Current treatments for cardiovascular disorders face limitations in addressing vascular integrity.
  • Developing advanced biomaterials for vascular repair is crucial for improving patient outcomes.

Purpose of the Study:

  • To fabricate and characterize a bioresorbable tubular stent for cardiovascular tissue regeneration.
  • To functionalize the stent with angiogenin to promote vascular healing.
  • To evaluate the mechanical properties, biocompatibility, and bioresorbability of the developed stent.

Main Methods:

  • Fabrication of a composite ink using silk fibroin (SF) and gelatin methacrylate (GelMA).
Keywords:
3D printingGelMAangiogenic cuesex vivo and in vivo studysilk fibrointubular stent

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Last Updated: Jun 12, 2026

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  • 3D printing of tubular stents and surface functionalization with angiogenin.
  • Rheological analysis, mechanical testing (tensile strength, elongation), bioresorbability, hemolysis, and cell viability assays.
  • Computational modeling to assess protein-stent binding.

    • Main Results:

    • The 15% SF-GelMA ink exhibited shear-thinning and thermosensitive sol-gel properties.
    • 3D-printed stents demonstrated mechanical stability (0.45 MPa tensile strength, 17% elongation) under wet conditions.
    • Angiogenin-functionalized stents showed 20-25% bioresorbability over 15 days, low hemolysis (1%), and enhanced cell viability (45% increase).
    • Computational modeling confirmed stable binding between angiogenic proteins and the stent.

    Conclusions:

    • A 3D-printed, angiogenin-functionalized SF-GelMA stent offers a promising approach for cardiovascular tissue regeneration.
    • The stent combines structural integrity, biocompatibility, and pro-angiogenic properties.
    • This biomaterial holds potential for developing advanced vascular grafts and regenerative therapies.