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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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Related Experiment Videos

Risk factors associated with apyrexia during bacteraemia: a prospective multicenter cohort study.

Pierre-Marie Roger1,2, Lucie Bocquillon3, Arnaud Lemasson4

  • 1, Infectiologie, Clinique Les Fleurs, 332, Ave Frédéric Mistral, Ollioules, 83190, France. roger@elsan.care.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|June 11, 2026
PubMed
Summary

Apyrexia (absence of fever) during bacteremia is common, especially in oncology patients and those with Enterococcus infections. Urinary tract infections, however, protect against apyrexia in bacteremia.

Keywords:
Enterococcus spAntibiotic therapyApyrexiaBacteraemiaRisk factors

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Epidemiology

Background:

  • Apyrexia during bacteremia is frequently observed, leading to diagnostic challenges.
  • Identifying risk factors for apyrexia in bacteremic patients is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the risk factors associated with apyrexia in patients diagnosed with bacteremia.
  • To improve the understanding of clinical presentations of bacteremia beyond fever.

Main Methods:

  • Prospective, bicentric study of positive blood cultures (PBC) over 27 months.
  • Exclusion of contaminated cultures; data collected from digital medical files.
  • Logistic regression analysis to identify risk factors for apyrexia despite bacteremia.

Main Results:

  • Out of 352 bacteremia cases, 20% presented with apyrexia.
  • Apyrexia was significantly associated with lack of prior antibiotic prescription (35% vs 13%).
  • Risk factors for apyrexia included oncology admission (aOR 2.03) and enterococcal bacteremia (aOR 4.01); urinary infections were protective (aOR 0.16).

Conclusions:

  • Apyrexia in bacteremia is not uncommon, particularly outside of urinary tract infections.
  • Oncology admission and Enterococcus spp. bacteremia are key risk factors for apyrexia.
  • Urinary tract infections appear to be a protective factor against apyrexia in bacteremic patients.