Related Experiment Video
Updated: Jun 13, 2026

07:33
In vitro Organoid Culture of Primary Mouse Colon Tumors
Published on: May 17, 2013
High-plasticity oncofetal cell states in early pre-metastatic colorectal cancer
Manon Bulliard1, Yakov Perlov1, Ömer H Yilmaz2
1Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cancer Cell
|June 11, 2026
Abstract:
In Nature, Buissant des Amorie et al. demonstrate that colorectal cancer acquires oncofetal cell states that resemble embryonic intestines, confer stem-like features, reshape epithelial identity, and prime cells for invasion and metastasis. Oncofetal cells are essential for metastasis and ubiquitous in non-metastatic tumors, with cancer-associated fibroblasts as key microenvironmental drivers.

