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Updated: Jun 13, 2026

Using Human Intestinal Organoids to Understand the Small Intestine Epithelium at the Single Cell Transcriptional Level
Published on: June 28, 2024
Leveraging Single-Cell and Spatial Transcriptomics in Gut Nutrition and Mucosal Immunology
1Department of Biological Sciences, Rutgers University, Newark, NJ, United States.
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In this editorial, we describe how single-cell transcriptomics is advancing the field of intestinal nutrition biology, as highlighted in recent studies. These studies have uncovered potential communication between epithelial and immune cells, generating innovative hypotheses regarding nutrient metabolism in the context of mucosal immunology. We also discuss how emerging spatial transcriptomics and in vivo labeling models may propel conventional technologies forward, in terms of uncovering physical cell-cell interactions and spatial cell-cell communication that can be modulated by nutrient intervention.

