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Related Experiment Video

Updated: Jun 13, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Epstein-Barr Virus in Brain Cancer-Friend or Foe?

Michał Brzozowski¹, Magdalena Góralczyk², Sylwester Bogacki³

¹Neurosurgery Department, 1st Clinical Military Hospital with Outpatient Clinic in Lublin, 20-049 Lublin, Poland.

International Journal of Molecular Sciences

|June 12, 2026

Summary

Epstein-Barr virus (EBV) DNA and proteins were found in brain tumors, particularly glioblastomas (GBs). Higher viral loads and antibodies in GB patients suggest EBV may play a role in glioma development.

Keywords:

EBV brain cancer glioblastoma

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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Published on: September 7, 2022

Area of Science:

Neuro-oncology
Viral oncology
Molecular biology

Background:

Epstein-Barr virus (EBV) is linked to various cancers.
Its specific role in brain cancers, especially high-grade gliomas, remains unclear.
Understanding EBV's contribution to glioma pathogenesis is crucial.

Purpose of the Study:

To investigate the prevalence and role of Epstein-Barr virus (EBV) in brain cancer.
To analyze EBV DNA, LMP-1 expression, viral load in CSF, and serological status in glioma patients.

Main Methods:

Analysis of EBV DNA and LMP-1 in 145 glioma tumor tissues.
Quantification of EBV DNA load in cerebrospinal fluid (CSF).
Detection of EBV-specific antibodies (anti-EBNA1, anti-EBVCA, anti-EA, anti-Zta) in patient serum.

Main Results:

EBV DNA detected in 28.9% of glioma samples (42/145), with higher prevalence in glioblastomas (GBs).
LMP-1 expression was significantly higher in GBs (92.8%) compared to other gliomas (35.7%).
GB patients showed significantly higher EBV DNA loads in CSF and elevated levels of EBV-specific antibodies.

Conclusions:

The findings indicate a significant association between EBV and high-grade gliomas, particularly glioblastomas.
Further research is necessary to elucidate the extent of EBV's contribution to glioma development and progression.
Investigating latent EBV genes in glioblastoma is vital for understanding viral infection's role in cancer.