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Updated: Jun 13, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Recent Advances in Microenvironment-Responsive Materials for Periodontitis Therapy.

Wenhan Ma1, Yutong Han1, Tong Cui1

  • 1School of Stomatology, Jinan University, Guangzhou 510632, China.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Intelligent biomaterials offer new precision therapies for periodontitis by responding to the disease microenvironment. These advanced materials target drug delivery for better treatment outcomes and tissue regeneration.

Keywords:
clinical translationmicroenvironment-responsive materialspathological microenvironmentperiodontitisspatiotemporal orchestration

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Last Updated: Jun 13, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

  • Biomaterials Science
  • Periodontology
  • Drug Delivery Systems

Background:

  • Periodontitis is a prevalent chronic inflammatory disease causing significant tissue destruction.
  • Current treatments like mechanical debridement and antibiotics have limitations in biofilm removal and drug efficacy.
  • There is a need for advanced therapeutic strategies to overcome these limitations.

Purpose of the Study:

  • To review recent advances in intelligent biomaterials for periodontitis treatment.
  • To explore microenvironment-responsive strategies for targeted drug delivery.
  • To provide a roadmap for developing next-generation precision therapies for periodontitis.

Main Methods:

  • Review of material platforms including hydrogels, microneedles, and nanoparticles.
  • Analysis of responsive designs based on pH, ROS, and enzymatic triggers.
  • Examination of spatiotemporal functional orchestration for different disease stages.

Main Results:

  • Intelligent biomaterials can modulate the pathological microenvironment of periodontitis.
  • Responsive strategies enable precise, on-demand drug delivery at the lesion site.
  • Integration of material platforms, responsive design, and functional orchestration is key.

Conclusions:

  • Intelligent biomaterials represent a promising approach for periodontitis precision therapy.
  • Addressing translational challenges like scalability and biosafety is crucial for clinical implementation.
  • This review offers guidance for developing advanced periodontitis treatments.