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Decoding Cyclodextrins in Skin Applications: Structure, Mechanisms, and Safety in Cosmetic and Dermatologic

Daniela-Ioana Mitrofan-Bandol^1,2, Ema-Teodora Nițu^1,2, Luciana Buliga^1,2

¹Doctoral School, "Victor Babeş" University of Medicine and Pharmacy, 2nd Eftimie Murgu Street, 300041 Timișoara, Romania.

International Journal of Molecular Sciences

|June 12, 2026

Summary

Cyclodextrins (CDs) enhance cosmetic ingredient stability and delivery. This review details how CD molecular structure impacts skin interaction and safety for advanced dermocosmetics.

Keywords:

botanical extracts cyclodextrins dermocosmetics molecular encapsulation regulatory framework safety assessment skin penetration topical delivery

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Area of Science:

Dermatologic and Cosmetic Sciences
Supramolecular Chemistry
Materials Science

Background:

Bioactive compounds in cosmetics often face solubility and stability issues.
Cyclodextrins (CDs) offer a promising solution as encapsulation platforms.
Understanding CD-skin interactions is crucial for effective topical formulations.

Purpose of the Study:

To systematically review the relationship between cyclodextrin molecular architecture and skin interface performance.
To analyze physicochemical properties, interaction mechanisms, and regulatory aspects of CDs for dermatologic applications.
To provide a foundational understanding for developing next-generation dermocosmetics.

Main Methods:

Comprehensive analysis of natural and derivative cyclodextrin physicochemical properties.
Evaluation of cyclodextrin interaction mechanisms with the skin barrier.
Synthesis of safety data, toxicological profiles, and review of regulatory frameworks.

Main Results:

Cyclodextrins' hydrophobic cavities effectively encapsulate botanical extracts, enhancing bioavailability and photostability.
Selected CDs can modulate skin penetration while maintaining epidermal barrier compatibility.
Specific cyclodextrin types demonstrate suitability for topical application based on safety and toxicological data.

Conclusions:

The molecular design and safety of cyclodextrin-based systems are critical for advanced dermocosmetics.
This review provides essential insights into cyclodextrin functionality for skin applications.
Further research into cyclodextrin applications is supported by this foundational analysis.