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Related Experiment Video

Updated: Jun 13, 2026

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
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Periorbital Structural and Functional Modulation Following Liquid-Type Polycaprolactone Treatment: A Pilot Study.

Sung Jay Choe1, Ju Hee Han2, Irene Darmawan3

  • 1Galleria Dermatology Skin Clinic, Seoul 06526, Republic of Korea.

Journal of Clinical Medicine
|June 12, 2026
PubMed
Summary

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This summary is machine-generated.

This study shows that a liquid polycaprolactone (PCL) collagen biostimulator improved periorbital aging, enhancing eyelid opening and infraorbital contour without direct eyelid injection.

Area of Science:

  • Aesthetic medicine
  • Dermatology
  • Regenerative medicine

Background:

  • Periorbital aging causes decreased eyelid opening and altered infraorbital contour.
  • Current collagen biostimulators offer limited regional tissue interaction.
  • A novel liquid-type polycaprolactone (PCL)-based collagen biostimulator was developed.

Purpose of the Study:

  • To assess structural and functional periorbital changes after PCL treatment.
  • To evaluate the efficacy of a novel liquid collagen biostimulator in the periorbital area.

Main Methods:

  • Three patients received PCL treatment via upper and lower periorbital approaches.
  • Clinical photographs were taken at baseline, 1 month, and 3 months.
  • Eyelid and infraorbital parameters, including canthal tilt angle (CTA), were measured.
Keywords:
collagen biostimulatoreyelid openingfunctional modulationinfraorbital contourliquid-type polycaprolactoneperiorbital rejuvenationtissue redistribution

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Main Results:

  • Margin reflex distance 1 (MRD1) increased, indicating improved eyelid opening.
  • Canthal tilt angle (CTA) increased, and infraorbital concavities (UC, PP, LC) decreased.
  • Indirect regional effects were observed without direct upper eyelid injection.

Conclusions:

  • Liquid-type PCL biostimulator treatment induced functional and structural periorbital changes.
  • Improved eyelid opening suggests indirect effects via contiguous anatomical planes.
  • Observed contour changes indicate broader structural and functional improvements in the lower eyelid.