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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 13, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Dynamic DNA Nanomachines for Biosensing and Drug Delivery.

Borui Zhang^1,2,3, Mengyao Sun^1,2,3,4, Jie Chao^1,2,3

¹State Key Laboratory for Flexible Electronics (LoFE), Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Sensors (Basel, Switzerland)

|June 12, 2026

Summary

DNA nanomachines, built with responsive DNA nanostructures, offer dynamic capabilities for biosensing and drug delivery. This review details their stimulus-response strategies and biomedical potential.

Keywords:

DNA nanostructures biosensing drug delivery dynamic nanomachines stimulus-response strategies

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Last Updated: Jun 13, 2026

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Area of Science:

Biotechnology
Nanotechnology
Molecular Biology

Background:

DNA nanotechnology utilizes base pairing for nanostructure construction.
Integration of stimuli-responsive modules enables dynamic DNA nanomachines.
These nanomachines show promise for biomedical applications.

Purpose of the Study:

To outline stimulus-response strategies in DNA nanostructures.
To review advances in nanomachines for biosensing and drug delivery.
To discuss challenges and prospects in clinical diagnosis and therapy.

Main Methods:

Review of molecular-driven and environmental stimulation mechanisms.
Analysis of recent applications in biosensing and drug delivery.
Discussion of current challenges and future directions.

Main Results:

Stimulus-response strategies enhance DNA nanostructure functionality.
Responsive DNA nanomachines are advancing biosensing and drug delivery.
Significant potential exists for clinical diagnosis and precision therapy.

Conclusions:

Responsive DNA nanomachines are a key area of development.
Biomedical applications in diagnostics and therapeutics are expanding.
Further research is needed to overcome clinical challenges.