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Inter-arm Blood Pressure Difference is Associated With Both Coronary Artery Disease and Peripheral Artery Disease in

Sávio Amaral1,2, Moises Alberto Suarez-Zdunek1, Andreas Dehlbæk Knudsen1

  • 1Viroimmunology Research Unit, Department of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.

Open Forum Infectious Diseases
|June 12, 2026
PubMed

Insights

High systolic inter-arm blood pressure difference (SIABPD) is common in people with HIV. This blood pressure variation is independently linked to widespread coronary and peripheral artery disease, highlighting a significant cardiovascular risk.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Disease Epidemiology

Background:

  • High systolic inter-arm blood pressure difference (SIABPD) is a known predictor of cardiovascular events.
  • Vascular complications are a significant concern for people living with HIV (PLWH).

Purpose of the Study:

  • To determine the prevalence of high SIABPD in PLWH.
  • To investigate the association between high SIABPD and coronary artery disease (CAD) and peripheral artery disease (PAD) in this population.

Main Methods:

  • Cross-sectional study evaluating SIABPD measurements.
  • Assessment of coronary and peripheral arterial disease severity.
  • Statistical analysis to determine independent associations.

Main Results:

  • The prevalence of high SIABPD was found to be 24% among the study participants.
  • SIABPD was independently associated with extensive coronary artery disease.
  • SIABPD was also independently associated with extensive peripheral arterial disease.

Conclusions:

  • A significant proportion of PLWH exhibit high SIABPD.
  • High SIABPD is an independent risk factor for advanced CAD and PAD in PLWH.
  • Screening for SIABPD may help identify PLWH at higher risk for vascular disease.

Keywords:
HIVblood pressurecoronary artery disease

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