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Updated: Jun 13, 2026

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

Published on: January 17, 2025

Spatial connectivity for local cortical homogeneity.

Xi-Nian Zuo¹, Ping Wang^1,2

¹State Key Lab of Cognitive Neuroscience and Learning, Beijing Normal University, No 19 Xinjiekouwai Street, Beijing, 100875, Beijing, China.

Research Square

|June 12, 2026

Summary

This summary is machine-generated.

We developed a new metric, spatial connectivity for local homogeneity in cortex (SoHo), to map primate brain organization. SoHo reveals conserved functional gradients across species, linking brain structure to function.

Keywords:

Spatial Connectivity Homogeneity functional brain parcellation functional diversity functional uniformity primate cortex spacetime concordance

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Visualization of Cortical Modules in Flattened Mammalian Cortices

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Published on: January 22, 2018

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Last Updated: Jun 13, 2026

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

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Published on: January 17, 2025

Visualization of Cortical Modules in Flattened Mammalian Cortices

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Published on: January 22, 2018

Area of Science:

Neuroscience
Primate Brain Mapping
Functional Connectivity Analysis

Background:

Understanding primate cortical organization requires metrics capturing temporal and topological functional connectivity.
Existing methods may not fully integrate continuous and discrete models of brain function.

Purpose of the Study:

To introduce and validate the spatial connectivity for local homogeneity in cortex (SoHo) metric.
To investigate the functional organization and evolutionary conservation of the primate cortex.

Main Methods:

Developed SoHo, a vertex-wise metric assessing local similarity of whole-brain functional connectivity profiles.
Validated SoHo using large-scale resting-state fMRI data from the Human Connectome Project (HCP) and NIH Marmoset Brain Mapping Project.

Main Results:

SoHo values closely corresponded with HCP atlas parcellation boundaries in humans, with low values at areal boundaries.
A gradient of functional uniformity (high SoHo) in primary sensorimotor areas and functional diversity (low SoHo) in association areas was observed.
Cross-species SoHo mapping demonstrated evolutionary conservation of the primary-to-association gradient and identified species-specific adaptations.

Conclusions:

SoHo effectively bridges discrete parcellation and continuous brain function models.
The SoHo metric provides novel insights into primate brain organization and evolution.
The primary-to-association functional gradient is an evolutionarily conserved feature of the primate cortex.