Suaeglaucin C: a new coumaronochromone isolated from Suaeda glauca

A new coumaronochromone (1), and 12 known compounds (2-13) were isolated from the ethyl acetate part of an aqueous EtOH extract of Suaeda glauca. Compounds 5-8 and 12 effectively ameliorated pericardial edema and venous congestion in zebrafish embryos induced by verapamil hydrochloride at 50 μM. Among these, 8 exhibited superior efficacy in reducing pericardial edema compared to the positive control, Digoxin. In contrast, 1-3 displayed significant lethality in zebrafish embryos, with LC₅₀ values of 9.41, 39.59, and 24.47 μM, respectively. Furthermore, these three compounds showed potential cytotoxic effects on HCT116 cells at 30 and 50 μM.