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Updated: Jun 13, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Risk factors associated with significant posttraumatic brain hemorrhage as per the QueBIC categories: A retrospective
Axel Benhamed1, Amandine Crombé, Rémy Matichard
1Centre de Recherche (A.B., M.E.), CHU de Québec-Université Laval, Québec, Québec, Canada; Service SAMU-Urgences (A.B., R.M., K.T.), Centre Hospitalier Universitaire Édouard Herriot-Université Claude Bernard Lyon 1, Lyon, France; IMADIS Groupe (A.C., M.S., D.M., G.G.), Lyon, France; Department of Diagnostic Oncologic Imaging (A.C.), Gustave Roussy Institute, Villejuif, France; Department of Radiology (A.C.), Pellegrin University Hospital, Bordeaux, France; Service de Médecine Intensive-Réanimation (L.F.), Centre Hospitalier Universitaire Edouard Herriot, Lyon, France; Department of Radiology (R.L.H.), Edouard Herriot Hospital, Lyon, France; Department of Radiology (D.M.), Saint Joseph Saint Luc Hospital, Lyon, France; Clinique Bouchard (G.G.), ELSAN, Marseille, France.
In complicated mild traumatic brain injury (mTBI), antithrombotic use, older age, confusion, and skull fracture predict higher risk. The Quebec Brain Injury Categories (QueBIC) stratification is mainly driven by these factors.
Area of Science:
- Neuroscience
- Trauma Surgery
- Radiology
Background:
- Mild traumatic brain injury (mTBI) rarely leads to severe complications.
- The Quebec Brain Injury Categories (QueBIC) stratifies risk based on CT findings.
- Pre-CT clinical predictors can optimize imaging and monitoring for complicated mTBI.
Purpose of the Study:
- Identify pre-CT clinical predictors of moderate/high QueBIC risk in complicated mTBI.
- Assess concordance between QueBIC and the Canadian CT Head Rule (CCHR).
Main Methods:
- Retrospective multicenter cohort study of adults with complicated mTBI.
- QueBIC categories assigned from radiology reports.
- Multivariable logistic regression to identify independent pre-CT predictors.
Main Results:
- Antithrombotic medication (antiplatelet, anticoagulants, dual therapy) increased moderate/high QueBIC risk.
- Older age (65-74, ≥75 years) was associated with higher risk.
- Confusion showed the strongest association (OR: 18.67), followed by suspected skull vault fracture (OR: 2.09).
Conclusions:
- Pre-CT risk in complicated mTBI is influenced by antithrombotic exposure, older age, confusion, and suspected skull fracture.
- CCHR shows moderate concordance with QueBIC and may overestimate risk.
- QueBIC-informed pathways can guide imaging and monitoring decisions.
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