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Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
High-Intensity Focused Ultrasound Versus Robot-Assisted Radical Prostatectomy for Localized Prostate Cancer: A
Si Ge1, Zhiqiang Zeng2, Lei Zheng3
1Department of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, China. gesi822927@126.com.
Annals of Surgical Oncology
|June 12, 2026
Summary
High-intensity focused ultrasound (HIFU) shows improved erectile function and urinary continence compared to robot-assisted radical prostatectomy (RARP) for localized prostate cancer. Oncologic outcomes require further long-term confirmation.
Area of Science:
- Urology
- Oncology
- Medical Technology
Background:
- Localized prostate cancer (LPCa) necessitates treatment comparison for optimal patient outcomes.
- High-intensity focused ultrasound (HIFU) and robot-assisted radical prostatectomy (RARP) are key treatment modalities.
Purpose of the Study:
- To compare functional and oncologic outcomes between HIFU and RARP for LPCa.
- Evaluate the efficacy and safety of these two prostate cancer treatments.
Main Methods:
- Systematic review of five cohort studies (n=2123) across four databases.
- Followed PRISMA 2020 and AMSTAR 2 guidelines.
- Pooled effect estimates using random-effects models.
Main Results:
- HIFU demonstrated significantly higher International Index of Erectile Function (IIEF)-5 scores at 6, 12, and 24 months.
- Urinary continence, measured by pad-free rates, favored HIFU at baseline, 6, and 12 months.
- No significant differences in International Prostate Symptom Score (IPSS) or salvage therapy rates were observed.
Conclusions:
- HIFU offers superior erectile function and urinary continence over RARP for localized prostate cancer.
- Complication and salvage therapy rates appear comparable between HIFU and RARP.
- Long-term oncologic outcomes for HIFU require further investigation.
