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Related Experiment Video

Updated: Jun 14, 2026

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

An injectable, leadless bioelectronic interface for battery-free wireless peripheral neuromodulation.

Mohamed Elsherif1, Salma Mansour1, Zhansaya Makhambetova1

  • 1Division of Engineering, New York University (NYU) Abu Dhabi, Abu Dhabi 129188, UAE.

Science Advances
|June 12, 2026
PubMed
Summary

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We developed SEED, a leadless, battery-free injectable bioelectronic device for peripheral nerve stimulation. This technology enables programmable neuromodulation via resonant inductive coupling, offering a minimally invasive therapeutic approach.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Medical Devices

Background:

  • Injectable bioelectronics offer minimally invasive peripheral nerve stimulation.
  • Current limitations include onboard energy storage and fragile leads.

Purpose of the Study:

  • To introduce SEED (Stimulating Electrode for Electroceutical Delivery), a leadless, battery-free bioelectronic interface for percutaneous delivery.
  • To demonstrate programmable neuromodulation without onboard active electronics.

Main Methods:

  • SEED utilizes low-frequency (65 kHz) resonant inductive coupling for wireless power and control.
  • A spiral-helix electrode geometry was designed for nerve engagement and reduced field spread.
  • Characterization involved benchtop, ex vivo, and in vivo (rat sciatic nerve) studies.

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Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
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Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

Related Experiment Videos

Last Updated: Jun 14, 2026

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

Main Results:

  • Precise, programmable control of stimulation parameters (frequency, pulse width, amplitude) was achieved.
  • In vivo studies confirmed frequency-locked motor responses and graded neural recruitment.
  • SEED demonstrated radiopacity and acoustic contrast for image-guided procedures.

Conclusions:

  • SEED offers a leadless, battery-free solution for minimally invasive peripheral nerve stimulation.
  • The platform enables programmable neuromodulation and is compatible with imaging modalities.
  • This technology presents a scalable pathway for future bioelectronic therapies.