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Updated: Jun 14, 2026
07:02
Animal Model of Implant-Associated Infections in Mice
Published on: June 27, 2025
Inside-Outside ROS Therapeutic Strategy Based on Piezoelectric Nano-Urchin for Drug-Resistant Bacteria Biofilm
Xinjian Guo1, Jin Yang2, Mengjie An1
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 12, 2026
Summary
A novel mechano-piezoelectric nano-urchin system disrupts biofilms using ultrasound. This system generates reactive oxygen species (ROS) for synergistic antimicrobial therapy, effectively clearing infections and promoting tissue repair.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Antimicrobial Therapy
Background:
- Biofilm-associated infections present significant clinical challenges due to antibiotic resistance.
- Conventional therapies struggle with biofilm penetration and efficacy.
Purpose of the Study:
- To develop a mechano-piezoelectric nano-urchin system for synergistic biofilm eradication.
- To investigate ultrasound-triggered mechanical disruption and hierarchical reactive oxygen species (ROS) generation.
Main Methods:
- Engineered NiCo2S4@UiO-66 nano-urchins with spiky architectures.
- Utilized ultrasound to activate mechanical disruption and ROS generation.
- Investigated dual ROS pathways: peripheral ·OH and internal 1O2 generation.
Main Results:
- The nano-urchin system achieved mechanical biofilm disruption.
- Ultrasound activation induced hierarchical ROS generation for synergistic antimicrobial effects.
- Demonstrated rapid biofilm clearance and accelerated tissue repair in a murine MRSA wound model.
Conclusions:
- The mechano-piezoelectric nano-urchin system offers an effective strategy for treating multidrug-resistant biofilm infections.
- This approach overcomes limitations of conventional antimicrobial therapies by combining mechanical and chemical actions.
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