Quantitativein-vivofull-waveform ultrasound tomography workflow integrating reflection imaging and resolution...

Objective.To demonstrate the potential of full-waveform inversion (FWI) for high-resolution ultrasonic imaging usingin-vivodata.Approach.Acoustic FWI is applied toin-vivomeasurements, accounting for the nonlinear relationship between the ultrasonic wavefield and model parameters. Two key components are investigated: (1) estimation of an effective source wavelet by inverting the source-time function using calibration data in water, and (2) reduction of nonlinearity and sensitivity to the initial model using a graph-space optimal transport misfit functional. A perturbation-based resolution analysis is employed to quantify local spatial smearing.Main results.The proposed approach enables improved spatial resolution in reconstructed models and allows accurate identification of anatomical features inin-vivodata.Significance.These results provide further evidence for the applicability of FWI toin-vivoultrasonic imaging and highlight methodological components that influence reconstruction quality, offering insight into its potential for clinical applications.