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Published on: June 8, 2022
Optoacoustic brain imaging: A systematic review and field mapping
Yikai Wang1, Amir Khansari2, Qingxiang Ding1
1Institute of Precision Optical Engineering, School of Physics Science and Engineering, Tongji University, Shanghai, China.
Photoacoustics
|July 28, 2026
Summary
Optoacoustic (OA) imaging offers high-resolution brain analysis by combining light and sound. This review details OA neuroimaging advances, applications, and future challenges for brain research.
Area of Science:
- Neuroimaging
- Biomedical Optics
- Medical Physics
Background:
- Optoacoustic (OA) imaging combines optical absorption contrast with ultrasonic detection for brain research.
- It overcomes optical diffusion limits, offering high resolution and molecular sensitivity.
- OA imaging enables mapping of cerebral vasculature, hemodynamics, and metabolism.
Purpose of the Study:
- To systematically review technological advances and biomedical applications of OA brain imaging.
- To provide a quantitative overview of the research landscape, including publication trends and geographical distribution.
- To identify key challenges and future directions in OA neuroimaging.
Main Methods:
- Systematic review of optoacoustic (OA) brain imaging literature.
- Analysis of worldwide research activity, publication trends, and geographical distribution.
- Summary of recent advances in OA microscopy, tomography, and multimodal platforms.
Main Results:
- The review maps the development and research landscape of OA neuroimaging.
- Recent advances in OA microscopy, tomography, and multimodal platforms are summarized.
- Applications in animal models of neurological disorders highlight functional and molecular biomarkers.
Conclusions:
- OA imaging is a powerful tool for multi-scale brain investigation.
- Emerging multimodal platforms enhance multiparametric interrogation of brain dynamics.
- Addressing challenges like spectral quantification and clinical translation is crucial for advancing OA neuroimaging.
