Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wernicke encephalopathy in non-alcoholic patients following gastrointestinal procedures: a systematic review.

Frontiers in surgery·2026
Same author

Anterior Cervical Hypertrichosis (Hairy Throat Syndrome): Pediatric Case Report and Brief Literature Review.

JMIR dermatology·2026
Same author

Prevalence of Eating Disorders Among Young Adults in the Western Region of Saudi Arabia.

International journal of preventive medicine·2026
Same author

Peer-to-Peer Prescribing Among Dermatologists.

Journal of the American Academy of Dermatology·2026
Same author

The Efficacy of Laser and Botox Therapies for Post-Thyroidectomy Scar Management: A Comprehensive Systematic Review and Meta-Analysis.

Aesthetic plastic surgery·2026
Same author

Adult Cutaneous Chronic Graft-Versus-Host Disease: An In-Depth Review.

Journal of cutaneous medicine and surgery·2026

Related Experiment Video

Updated: Jun 14, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Immune checkpoint inhibitor-associated autoimmune bullous disease: A clinical review.

Houriah Y Nukaly1, Ghassan Barnawi2, Husna Irfan Thalib3

  • 1Division of Experimental Medicine, McGill University Health Centre, Montréal, Québec, Canada.

Journal of the American Academy of Dermatology
|June 12, 2026
PubMed
Summary

Immune checkpoint inhibitors (ICIs) can trigger rare blistering skin conditions. Early diagnosis and tailored management are crucial for balancing cancer treatment with patient safety.

Keywords:
bullous dermatosesbullous pemphigoidcancer immunotherapydermatitis herpetiformisimmune checkpoint inhibitorsimmunobullous dermatosespemphigus vulgaris

Related Experiment Videos

Last Updated: Jun 14, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Oncology
  • Immunodermatology

Background:

  • Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy.
  • ICI use is linked to immune-related adverse events, including immunobullous dermatoses.

Purpose of the Study:

  • To review the pathogenesis, diagnosis, and management of ICI-induced immunobullous dermatoses.
  • To highlight challenges in managing these conditions.

Main Methods:

  • Clinical review of existing literature.
  • Analysis of diagnostic strategies including histopathology and immunofluorescence.
  • Review of management approaches, including corticosteroids, immunosuppressants, and biologics.

Main Results:

  • ICI-induced immunobullous dermatoses mimic autoimmune counterparts but have unique features like delayed onset and mucosal involvement.
  • Diagnosis requires a combination of clinical, histopathological, and immunopathological findings.
  • Management involves immunosuppression, with careful consideration of ICI continuation.

Conclusions:

  • ICI-induced immunobullous dermatoses pose diagnostic and therapeutic challenges.
  • Individualized treatment plans are essential to balance oncologic benefit and autoimmune toxicity.
  • Multidisciplinary collaboration between dermatology and oncology is vital.