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Updated: Jun 16, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

Reversing the Fold: Polyanionic Macrocycle Dissolves αA66-80 Crystallin Peptide Aggregates

Frank Boateng Osei1, Yuvraj Dangat2, Roi Yasay1

  • 1Department of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.

Biomacromolecules
|June 13, 2026
PubMed
Summary

A novel compound, MR-8S, effectively breaks down protein aggregates linked to cataract formation. This resorcinarene derivative shows significant deaggregation capabilities, offering potential for new anticataract drug development.

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