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ASSESSMENT OF THE LIPID SPECTRUM IN GEORGIAN CHILDREN WITH TYPE 1 DIABETES MELLITUS
D Rekhviashvili1, G Chakhunashvili2, M Chkhaidze3
11David Aghmashenebeli University of Georgia, Tbilisi, Georgia.
Georgian Medical News
|June 14, 2026
Summary
Poor glycemic control in children with type 1 diabetes mellitus (T1DM) is linked to unhealthy lipid profiles. Higher HbA1c levels predict dyslipidemia, emphasizing the importance of monitoring lipid indices in pediatric T1DM management.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Risk Assessment
- Metabolic Disorders
Background:
- Children and adolescents with type 1 diabetes mellitus (T1DM) face elevated cardiovascular disease risk.
- Dyslipidemia is a key modifiable risk factor in this population.
- Atherogenic lipid indices offer sensitive cardiovascular risk markers.
Purpose of the Study:
- To evaluate lipid profiles in Georgian children with T1DM.
- To determine the relationship between glycemic control and dyslipidemia in pediatric T1DM patients.
Main Methods:
- Retrospective cross-sectional study of 230 children and adolescents (9-18 years) with T1DM.
- Assessed lipid parameters (TC, LDL-C, HDL-C, TG, non-HDL-C) and atherogenic indices (e.g., AIP).
- Dyslipidemia defined by pediatric criteria; statistical analysis using SPSS v23.
Main Results:
- Inadequate glycemic control (HbA1c≥7%) correlated with significantly higher TC, LDL-C, TG, non-HDL-C, and atherogenic indices.
- Age and HbA1c were independent predictors of dyslipidemia.
- Sex was not found to be a predictor of dyslipidemia.
Conclusions:
- Inadequate glycemic control (HbA1c≥7%) in pediatric T1DM is associated with adverse atherogenic lipid profiles.
- Atherogenic lipid indices provide a comprehensive assessment of cardiovascular risk in T1DM.
- HbA1c is a significant independent predictor of dyslipidemia in children with T1DM.
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