THE IMPACT OF BARIATRIC SURGERY ON TYPE 2 DIABETES MELLITUS REMISSION IN THE GEORGIAN POPULATION

Obesity and diabetes are two closely related diseases that increase morbidity and mortality. Our study aims to investigate the effect of bariatric surgery on diabetes remission.

We studied 91 patients with type 2 diabetes mellitus (T2DM) and morbid obesity who underwent bariatric surgery-sleeve gastrectomy-at the "David Abuladze Georgian-Italian Clinic" from 2015-2022. The patients' ages ranged from 23 to 67 years (46.67±8.60), including 50 women and 41 men.

After the surgery, all patients reported weight loss (kg): before the surgery 146.80±25.81, after the surgery 97.87±17.56. t= 23.30, p <0.0001 the relative chance of remission after bariatric surgery increases Weight (kg) - OR=1.03(95% CI:1,02-1.05) and reduce Glycemia - Fasting >125 mg /dL - OR=0.06(95% CI:0.01-0.60); Sulfonylurea - OR=0.07(95% CI:0.02-0.27); Insulin - OR=0.06(95% CI:0.01-0.56) Conclusions: • Bariatric surgery in patients with type 2 diabetes promotes long-term remission of diabetes. • Positive predictor of complete remission is the patient's initial weight before bariatric surgery. Treatment and high glycemia (fasting >125 mg/dL) before surgery reduce the relative probability of complete remission. • Weight loss as a predictor of complete remission shows high sensitivity and specificity (cutoff value = 37.5kg).