Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progression.

Journal of orthopaedic translation·2026
Same author

Hip-preserving treatment of early ONFH via arthroscopy: preoperative finite element analysis planning with 3D printing assistance.

Scientific reports·2026
Same author

Engineering Nanomaterials for the Treatment of Intervertebral Disc Degeneration: From Application to Therapeutic Mechanisms.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Constitutive activation of activin receptor-like kinase 3 in chondrocytes exacerbates skeletal dysplasia in mice with achondroplasia.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025
Same author

Advances in the mechanism and therapies of achondroplasia.

Genes & diseases·2025
Same author

Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.

Journal of advanced research·2024
Same journal

Multifunctional material platforms for neural interfaces: active orchestration of dynamic foreign body response across implantation lifetimes.

Bioactive materials·2026
Same journal

Immune cell-derived membrane nanovesicles: A promethean fire for autoimmune disease therapy through immune cell mimicry.

Bioactive materials·2026
Same journal

Modulation of innate and adaptive immunity by pH-responsive nanozyme-like nanoparticles with high mobility for rheumatoid arthritis alleviation.

Bioactive materials·2026
Same journal

A senescent metabolism-modulating hierarchical scaffold restores NAD<sup>+</sup> homeostasis and redox balance for aged bone repair.

Bioactive materials·2026
Same journal

Intelligent responsive alloy scaffold temporally regulates the immune-osteogenic axis for the treatment of infectious bone defects.

Bioactive materials·2026
Same journal

Polymer-Zn(II) sunscreens for protection against harmful blue ray.

Bioactive materials·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

Materialogenetics: an emerging and promising framework for cell-specific genetic manipulation.

Fengtao Luo1, Tao Song1, Hangang Chen1

  • 1Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Bioactive Materials
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Materialogenetics integrates biomaterials with genetic manipulation technologies (GMTs) for precise cell control. This approach overcomes limitations in studying complex tissues, offering a tunable and cost-effective platform for genetic research.

Keywords:
BiomaterialsCell state responseCell targetingGenetic manipulation

More Related Videos

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
06:40

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun

Published on: October 24, 2014

Related Experiment Videos

Last Updated: Jun 16, 2026

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
06:40

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun

Published on: October 24, 2014

Area of Science:

  • Biomaterials Science
  • Genetics
  • Molecular Biology

Background:

  • Genetic manipulation technologies (GMTs) are crucial for understanding biological processes.
  • Cellular heterogeneity in complex tissues challenges the precision of current GMTs.
  • Existing GMTs have limitations in achieving cell-specific genetic regulation.

Purpose of the Study:

  • To address the limitations of current GMTs in complex biological systems.
  • To propose a novel framework, Materialogenetics, for enhanced genetic manipulation.
  • To demonstrate the potential of integrating biomaterials with GMTs using fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling in osteoarthritis (OA) as a model.

Main Methods:

  • Conceptual framework development integrating biomaterials science and GMTs.
  • Leveraging active-targeting and stimuli-responsive biomaterials.
  • Utilizing osteoarthritis research involving FGF/FGFR signaling to illustrate technical limitations.

Main Results:

  • Materialogenetics offers a theoretical framework for improved cell-specific and spatiotemporally controlled genetic manipulation.
  • Biomaterial-assisted genetic manipulation presents advantages like cost-effectiveness, operational simplicity, and tunability.
  • The proposed framework enhances the applicability of GMTs in complex biological systems.

Conclusions:

  • Materialogenetics provides a versatile platform for precise genetic manipulation in complex biological systems.
  • This interdisciplinary approach bridges materials science and genetics.
  • It represents a promising strategy for advancing biological research and therapeutic applications.