Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 16, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Essential Tremor and Digital Biomarkers: A Scoping Review Using the TRACE Framework to Map Readiness for Clinical

David Ledingham1,2,3,4, Antonella Macerello5,6, Nicola Pavese1,2,3,7,4

  • 1Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|June 15, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Noradrenergic Brain in Parkinson's Disease.

Current neurology and neuroscience reports·2026
Same author

Clinical prognostic indicators in multiple system atrophy.

Brain : a journal of neurology·2026
Same author

Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol.

BMJ open·2026
Same author

Alzheimer's Biomarkers and Visuospatial Cognition in Parkinson's Disease: Modification by α-Synuclein and Mediation of Age Effects.

Movement disorders clinical practice·2026
Same author

Spinal cord stimulation therapy for gait impairment in Parkinson's disease: a double-blinded, randomised feasibility trial with an open extension.

Nature communications·2026
Same author

Pathogenic or Likely Pathogenic GRN Variants Are Found in 0.1% of Parkinson's Disease Patients.

Movement disorders : official journal of the Movement Disorder Society·2025
This summary is machine-generated.

Essential tremor digital biomarkers show basic clinical validity but lack readiness for trials. The TRACE framework reveals only two studies achieved clinical trial readiness, highlighting a translational gap.

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Digital Health

Background:

  • Essential tremor (ET) is a common movement disorder with limited digital biomarker research.
  • A significant translational gap exists due to the lack of validated digital endpoints for ET therapies.
  • The TRACE (Technology Readiness And Clinical Evidence) framework is introduced to assess digital biomarker maturity.

Purpose of the Study:

  • To conduct a scoping review of digital biomarker research in essential tremor.
  • To apply the novel TRACE framework to evaluate the validation status of ET digital biomarkers.
  • To identify gaps in the development and validation of digital tremor outcome measures.

Main Methods:

  • A PRISMA-ScR scoping review of studies from 2000-2025 across four databases.
Keywords:
Clinical trialsDigital biomarkersEssential tremorScoping ReviewTRACE frameworkWearable sensors

More Related Videos

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test
08:07

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Related Experiment Videos

Last Updated: Jun 16, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test
08:07

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

  • Inclusion criteria: quantitative digital tremor measurement in ≥10 ET participants.
  • Studies were categorized using the five-tier TRACE framework (T1-T5).

    • Main Results:

    • 165 studies were reviewed, utilizing modalities like wearables (n=114), handwriting (n=16), and computer vision (n=15).
    • 93% (154 studies) met Tier 2 (referenced clinical validity); 9 studies reached Tier 3, and 2 reached Tier 4 (Cala Health TAPS wristband).
    • Only 11 studies demonstrated ambulatory/longitudinal evidence beyond supervised validation; no studies reached Tier 5.

    Conclusions:

    • Most ET digital biomarkers achieve basic clinical validity but fall short of trial readiness.
    • The Cala Health TAPS wristband is the only platform to reach Tier 4 validation.
    • Further research is needed on home deployment, minimum detectable change, and patient-reported outcomes for digital tremor metrics to serve as reliable endpoints.